TAME Trial Expansion: Metformin's Potential as Anti-Aging Drug
The Targeting Aging with Metformin (TAME) trial announces major expansion, adding new research centers and participants in this landmark study of aging intervention.
Expansion Highlights
Participant Growth
Participant pool expanded from 3,000 to 5,000 individuals, aged 65-79, providing more robust data for age-related outcomes.
New Centers
Addition of 12 new research centers across North America and Europe, bringing the total to 25 participating institutions.
Extended Duration
Study timeline extended to 8 years to capture long-term effects and age-related outcomes more comprehensively.
Enhanced Monitoring
Implementation of advanced biomarker tracking and cognitive assessment protocols across all centers.
About TAME Trial
The TAME (Targeting Aging with Metformin) trial is the first large-scale study designed to test whether a drug can slow the aging process and delay the onset of age-related diseases. Metformin, a widely-used diabetes medication, has shown promising potential in previous studies to influence multiple aging pathways.
This FDA-approved trial aims to establish aging itself as a treatable condition, potentially revolutionizing how we approach age-related diseases and longevity medicine.
Research Objectives
Primary Endpoints
Measure the impact of metformin on the development of multiple age-related conditions simultaneously.
Biomarker Analysis
Track comprehensive set of aging biomarkers to understand metformin's mechanisms of action.
Quality of Life
Evaluate improvements in healthspan and functional capacity in the aging population.
Potential Impact
If successful, the TAME trial could:
- Establish aging as an FDA-targetable indication
- Create a pathway for testing other potential anti-aging compounds
- Transform preventive medicine approaches
- Lead to new therapeutic strategies for age-related diseases
The expansion of this trial represents a significant step forward in aging research and could accelerate the development of interventions that extend healthy human lifespan.